Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn’s Disease
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چکیده
منابع مشابه
Endogenous Retroviruses and the Human Genome: Implications for Human Disease
Introduction Lifecycle and Genome Organization Endogenization Process and Host-Virus Evolution Classification of HERVs HERV Manipulation of Host Function Host Defenses against HERVs Cancer Multiple Sclerosis Schizophrenia Azoospermia Conclusions Sources Abstract Human endogenous retroviruses (HERVs) constitute approximately 8% of the human genome (16, 22, 39, 55). These ancient retroviruses rep...
متن کاملHuman endogenous retroviruses and chosen disease parameters in morphea
INTRODUCTION Morphea (localized scleroderma) is a relatively rare disease characterized by excessive skin fibrosis. Human endogenous retroviruses (HERV) are largely distributed within the human genome with hundreds of thousands of elements. The HERV have been widely studied in autoimmune disorders, yet hardly ever assessed in diseases with a good prognosis such as morphea. AIM In this study w...
متن کاملHuman endogenous retroviruses and cancer
Human endogenous retroviruses (HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution. About 8% of our genome is composed of HERVs, most of which are nonfunctional because of epigenetic control or deactivating mutations. However, a correlation between HERVs and human cancer has been described and many tumors, such as melanoma, brea...
متن کاملEndogenous Retroviruses and Human Evolution
Humans share about 99% of their genomic DNA with chimpanzees and bonobos; thus, the differences between these species are unlikely to be in gene content but could be caused by inherited changes in regulatory systems. Endogenous retroviruses (ERVs) comprise approximately 5% of the human genome. The LTRs of ERVs contain many regulatory sequences, such as promoters, enhancers, polyadenylation sign...
متن کاملEnv-less endogenous retroviruses are genomic superspreaders.
Endogenous retroviruses (ERVs) differ from typical retroviruses in being inherited through the host germline and therefore are a unique combination of pathogen and selfish genetic element. Some ERV lineages proliferate by infecting germline cells, as do typical retroviruses, whereas others lack the env gene required for virions to enter cells and thus behave like retrotransposons. We wished to ...
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ژورنال
عنوان ژورنال: Inflammatory Intestinal Diseases
سال: 2018
ISSN: 2296-9403,2296-9365
DOI: 10.1159/000494026